Ghost in the Shell (1995)
This classic Japanese manga animation (remade this year by Hollywood as a live action film starring Scarlett Johansson) is very definitely an adult thriller (with plenty of nudity and violence), about a cyborg policewoman on the hunt for a superhacker called the Puppet Master. Brilliantly exciting and innovative, the film showed that cartoons could not only be aimed at grown-ups, but could also address existential issues about the terrifying implications of technology taking over.
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