Ghost in the Shell (1995)

This classic Japanese manga animation (remade this year by Hollywood as a live action film starring Scarlett Johansson) is very definitely an adult thriller (with plenty of nudity and violence), about a cyborg policewoman on the hunt for a superhacker called the Puppet Master. Brilliantly exciting and innovative, the film showed that cartoons could not only be aimed at grown-ups, but could also address existential issues about the terrifying implications of technology taking over.

https://www.youtube.com/watch?v=JtxWNFfKTok